Ameela in Maidenhead

Clinical overview

Ameela is a CE-marked polynucleotide gel derived from highly purified DNA fragments. It works as a biostimulator, activating the skin’s own repair mechanisms at a cellular level. The polynucleotides stimulate fibroblast activity, supporting the natural production of collagen, elastin and hyaluronic acid within the dermis. The Ameela range includes formulations designed for different treatment areas and skin concerns. Ameela delivers polynucleotides in a gel matrix that provides controlled, sustained release within the skin. Treatment involves carefully placed microinjections into targeted areas such as the face, under-eyes, neck, décolletage and hands. A typical course involves 2–4 sessions spaced 2–4 weeks apart. Results are gradual, developing over 2–3 months as the skin’s regenerative response progresses. Ameela is not a dermal filler and does not add volume or change facial shape — the goal is improvement in skin quality including hydration, texture, elasticity and overall radiance.

Key Benefits

• Stimulates the skin’s natural repair and regeneration processes
• Improves skin hydration, elasticity and overall quality
• Supports smoother texture and a healthier-looking glow
• Can improve the appearance of fine lines and crepey skin
• Suitable for delicate areas including under-eyes, neck and hands
• Works well as part of a personalised skin rejuvenation plan

Suitable For

• Adults looking to improve skin quality (texture, hydration, elasticity)
• Those with dull, dehydrated or tired-looking skin
• Patients with crepey or thinning skin in areas such as under-eyes, face, neck or hands
• Those wanting gradual, natural-looking improvement rather than added volume
• Patients considering regenerative options where skin repair and resilience are the priority
• Those open to a course of treatments for cumulative improvement

Not Suitable For

• Pregnant or breastfeeding patients
• Patients with active infection or inflammation in the treatment area
• Those with certain autoimmune or immune-mediated conditions (case-by-case assessment required)
• Anyone with known allergy or previous significant reaction to polynucleotide products or their ingredients
• Those expecting volume restoration, lift or structural change from this treatment

Final suitability is confirmed during a medical consultation and assessment.

When we don't recommend it

• If your primary concern is volume loss or structural support — Ameela does not add volume and a different treatment plan may be more appropriate.
• If you have active infection, inflammation or compromised skin in the treatment area — treatment should be delayed until the area is healthy.
• If autoimmune or immune-mediated conditions have not been assessed — these require careful clinical evaluation before proceeding.
• If expectations are for rapid or dramatic results — Ameela produces gradual improvement over several weeks to months.
• If a combination plan (such as skincare optimisation first, then staged treatments) is likely to produce a safer or more effective result.

What Happens During Treatment

1. 1Consultation, medical history and suitability assessment
2. 2Discussion of goals, areas to treat and realistic outcomes
3. 3Skin cleansing and preparation of the treatment area
4. 4Topical anaesthetic may be applied depending on the area
5. 5Carefully placed microinjections using a technique suited to the treatment area
6. 6Aftercare guidance and follow-up plan discussed

Downtime & Aftercare

• Most people return to normal activities the same day
• Possible temporary redness, swelling or small bumps at injection sites
• Bruising is possible, particularly around the eyes
• Avoid heavy exercise, alcohol and heat exposure for 24–48 hours (individual advice may vary)
• Results develop gradually over the following weeks and months

Results Timeline

• Immediately after: mild redness, swelling or small bumps at injection sites (varies).
• Days 2–7: early improvements in hydration and skin comfort may be noticed.
• Weeks 2–6: skin texture and overall quality typically become clearer.
• Months 2–3: cumulative improvement develops as the regenerative response progresses.

Individual results vary. View our results and photography standards

Risks & Side Effects

Common, Usually Temporary

• •Temporary redness, swelling or tenderness in the treated area.
• •Small bruises at injection sites.
• •Temporary itching or sensitivity (varies).

Frequently Asked Questions