Polynucleotides in Maidenhead

Clinical overview

Polynucleotides are highly purified DNA-derived molecules, typically sourced from salmon or trout DNA. They act as biostimulators, working at a cellular level to support the skin’s natural repair and regeneration processes. The mechanism involves stimulating fibroblast activity, which in turn supports the production of collagen, elastin and hyaluronic acid within the dermis. Treatment involves carefully placed injections into targeted areas. Common treatment zones include the face (around the eyes, mouth and cheeks), neck, décolletage and hands. Products used may include Ameela, Plinest, Julaine or Purasomes, selected based on the treatment area and clinical assessment. A typical course involves 2–4 sessions spaced 2–4 weeks apart. Results are gradual, developing over 2–3 months as the skin’s regenerative response progresses. Polynucleotides are not dermal fillers and do not add volume or change facial shape — the goal is improvement in skin quality such as hydration, texture, elasticity and resilience.

Key Benefits

• Improves skin hydration and overall skin quality
• Supports smoother texture and a healthier-looking glow
• Can improve the appearance of fine lines (skin quality-focused)
• May help improve crepey or thinning-looking skin
• Often used in delicate areas such as under-eyes, neck and hands
• Works well as part of a personalised skin regeneration plan

Suitable For

• Adults looking to improve skin quality (texture, hydration, elasticity)
• Those with crepey or thinning-looking skin in areas such as under-eyes, face, neck or hands
• Patients wanting gradual, natural-looking improvement rather than added volume
• Those considering regenerative options where skin repair and resilience are the priority
• Patients open to a course of treatments for cumulative improvement

Not Suitable For

• Pregnant or breastfeeding patients
• Patients with active infection or inflammation in the treatment area
• Those with certain autoimmune or immune-mediated conditions (case-by-case assessment required)
• Anyone with known allergy or previous significant reaction to polynucleotide products or their ingredients
• Those expecting volume restoration, lift or structural change from this treatment

Final suitability is confirmed during a medical consultation and assessment.

When we don't recommend it

• If your primary concern is volume loss or structural support — polynucleotides do not add volume and a different plan may be more appropriate.
• If you have active infection, inflammation or compromised skin in the treatment area — treatment should be delayed until the area is healthy.
• If autoimmune or immune-mediated conditions have not been assessed — these require careful clinical evaluation before proceeding.
• If expectations are for rapid or dramatic results — polynucleotides produce gradual improvement over several weeks to months.
• If a combination plan (such as skincare optimisation first, then staged treatments) is likely to produce a safer or more effective result.

What Happens During Treatment

1. 1Consultation, medical history and suitability assessment
2. 2Discussion of goals, areas to treat and realistic outcomes
3. 3Skin cleansing and preparation of the area
4. 4Topical anaesthetic may be used depending on area and technique
5. 5Carefully placed injections using an approach suited to the area
6. 6Aftercare guidance and follow-up plan

Downtime & Aftercare

• Most people return to normal activities the same day
• Possible temporary redness, swelling or small bumps at injection sites
• Bruising is possible (more common around the eyes)
• Avoid heavy exercise, alcohol and heat exposure for 24–48 hours (individual advice may vary)
• Results develop gradually over the following weeks

Results Timeline

• Immediately after: mild redness, swelling or small bumps at injection sites (varies).
• Days 2–7: early improvements in hydration and skin comfort may be noticed (varies).
• Weeks 2–6: skin texture and overall skin quality typically become clearer (varies).
• Months 2–3: cumulative improvement develops as the regenerative response progresses.

Individual results vary. View our results and photography standards

Risks & Side Effects

Common, Usually Temporary

• •Temporary redness, swelling or tenderness in the treated area.
• •Small bruises at injection sites.
• •Temporary itching or sensitivity (varies).

Frequently Asked Questions